Retatrutide

GIP / GLP-1 / Glucagon Triple Receptor Agonist

Retatrutide (LY3437943) is a single synthetic peptide molecule that acts as a triple agonist at the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon (GCG) receptors. This tri-receptor mechanism distinguishes it from dual agonists like tirzepatide and makes it a subject of intense interest in metabolic research. Preclinical and early clinical studies have explored its role in energy expenditure, lipid metabolism, and glucose homeostasis. Its glucagon receptor activity is believed to contribute to enhanced energy expenditure compared to GLP-1 or dual agonists alone.